Saonli Basu has research interests in the development of methods for inference from human genome data. Her primary focus is developing methods for linkage analysis using large complex pedigrees. Her areas of interest also include computational statistics and nonparametric inferences.
- PhD in Statistical Genetics track, Department of Statistics, University of Washington, Seattle, WA
- MS in Applied Statistics and Data Analysis, Indian Statistical Institute, Calcutta, India
- BS in Statistics, Presidency College, Calcutta, India
- 2005 (September) – Present, Assistant Professor, Division of Biostatistics, School of Public Health, University of Minnesota.
- 2000 – 2005 (August), PhD Student, University of Washington, Department of Statistics.
- 1999 – 2000, Research Associate, Department of Statistics, Indian Statistical Institute.
- 1998 – 1999, Research Associate, Market Research, ORG MARG, India.
- 2004, ENAR Distinguished Student Paper Award Winner. 2003, Travel Award for Rockefeller Advanced Linkage Course.
A gene-set approach for pathway analysis of genome-wide
Principal Investigator: Saonli Basu
Funding Agency: NIH NIDDK NATL INST OF DIABETE
A gene-set approach for pathway analysis of genome-wide
A likelihood-based approach for detecting gene-gene interaction in a case-control study
Principal Investigator: Saonli Basu
Funding Agency: MN MED FDN
A likelihood-based approach for detecting gene-gene interaction in a case-control study
- He, H., Oetting, W. S., Brott, M. J., Basu, S. (2009), Pair-wise multifactor dimensionality reduction method to detect gene-gene interactions in a case-control study. Human Heredity 2010;69(1):60-70.
- He, H., Oetting, W. S., Brott, M. J., Basu, S.. (2009), Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study. BMC Med Genet. 2009 Dec 4;10(1):127.
- Basu S, Stephens M, Pankow JS, Thompson EA (2009), A likelihood-based trait-model-free approach for linkage detection of binary trait. Biometrics, Vol 66(1):205-13.
- Basu S (2007), Allele-sharing methods on extended pedigrees, Sankhya, Vol 69 (3): 405-424.
- Basu S, Di Y and Thompson EA (2008), Exact Trait-Model-Free Tests for Linkage Detection in Pedigrees, Annals of Human Genetics, Vol 72(5): 676-682.
- Thompson, E.A. and Basu, S. (2003), “Genome Sharing in large pedigrees: multiple imputation of ibd for linkage detection”, Human Heredity,Vol 56, 119-125.
- rr2008-005.pdf – Basu, S., Stephens, M. and Thompson, E.A.A likelihood-based trait-model-free approach for linkage detection of binary traitResearch Report 2008-5, Division of Biostatistics, University of Minnesota, 2008Biometrics (to appear).
Ph.D., 2010, Biostatistics, University of Michigan Statistical genetics, identification of genes involved in complex diseases and traits, with a special emphasis on developing statistical and analytical methods for the genetic data with new high-throughput technologies.
- Ph.D., 2010, Biostatistics, University of Michigan
Biostatistics, Genetics, Statistical Genetics
Psychiatric GWAS Consortium Bipolar Disorder Working Group
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Research Report 2011-39, Division of Biostatistics, University of Minnesota, 2011
Ramsuran V, Kulkarni H, He W, Mlisana K, van Loggerenberg F, Wright EJ, Werner L, Castiblanco-Quinche J, Dolan MJ, Guan W, Weiss RA, Clark RA, Abdool Karim SS, Ahuja SK, Ndung’u T
Duffy-null-associated low neutrophil counts influence hiv-1 susceptibility in high-risk south african black women
Research Report 2011-40, Division of Biostatistics, University of Minnesota, 2011
Clinical Infectious Diseases
Jacobson PA, Schladt D, Oetting W, Leduc R, Guan W, Lamba V, Matas A, Mannon R, Julian BA, Israni A
Genetic determinants of mycophenolate related anemia and leukopenia following transplantation
Research Report 2011-41, Division of Biostatistics, University of Minnesota, 2011
Jacobson P, Oetting W, Brearley A, Leduc R, Guan W, Lamba V, Matas A, Mannon R, Julian BA, Israni A.
Novel polymorphisms associated with tacrolimus trough concentrations: results from a ulticenter kidney transplant consortium
Research Report 2011-42, Division of Biostatistics, University of Minnesota, 2011
Israni A, Leduc R, Holmes J, Jacobson P, Lamba V, Guan W, Schladt D, Chen J, Matas A, Oetting W
Single nucleotide polymorphisms, acute rejection and severity of tubulitis in kidney transplantation, accounting for center-to-center variation.
Research Report 2010-32, Division of Biostatistics, University of Minnesota, 2010
Yen-Yi Ho earned her Ph.D. from Johns Hopkins University. Her research interests include computational biology, statistical genetics, and statistical applications in biomedical research. Currently, her focus is on developing statistical methods and computational tools using large-scale genomic data. Dr. Ho is a member of the biostatistics core of the University of Minnesota Cancer Center.
- Ph.D., 2009, Biostatistics, Johns Hopkins University
- M.S., 2001, Epidemiology, National Taiwan University
- B.S., 1999, Double major in Medical Technology and Public Health, National Taiwan University
My general research interests include computational biology, statistical genetics and statistical consulting. I am particularly interested in developing statistical methods for analyzing genetic data generated by high-throughput technologies, and gene pathway/network enrichment analysis. Currently my scientific interests include applications in genetic mechanisams for cancer, chemotherapy response, and personalized medicine. I am a member of the Biostatistics Shared Resource Core in the Masonic Cancer Center at the University of Minnesota.
- Ho, Y.-Y., Cope, L.M., Parmigiani, G. (2011). nPARS: A comprehensive search algorithm for constructing Bayesian networks using large-scale genomic data. (Submitted)
- Jiang, Q., Ho, Y.-Y., Hao L, Nichols Berrios C, Chakravarti, A. (2011). Copy number variants in candidate genes are genetic modifiers of Hirschsprung disease. PLoS One 6, e21219.
- Ho, Y.-Y., Matteini A.M., Beamer B., and Fried L., et al. (2011). Exploring biologically relevant pathways in frailty. Journal of Gerontology A Biological Sciences and Medical Sciences 66 975-979.
- Ho, Y.-Y., Parmigiani, G., Louis, T.A., Cope, L.M. (2010). Modeling Liquid Association. Biometrics 67, 133-141. doi: 10.1111/j.1541-0420.2010.01440.x
- Ho, Y.-Y. (2009). LiquidAssociation: R/Bioconductor package for estimating liquid association using the conditional normal model. Available at http://www.bioconductor.org
- Ho, Y.-Y., Cope, L., Dettling, M., and Parmigiani, G. (2007). Statistical methods for identifying differentially expressed gene combinations. Methods in Molecular Biology 408, 171-191.
- Lee, W.-C., Ho, Y.-Y. (2003). Potential for gene-gene confounding bias in case-parental control studies. Annals of Epidemiology 13, 261-266.
- Chen, W.J., Liu P.-H., Ho, Y.-Y., and Chien, K.-L., et al. (2003). Sibling re-currence risk ratio analysis of the metabolic syndrome and its components over time. BMC Genetics 4, S33-S28.
Heather Nelson received her MPH from the University of Minnesota and a PhD in Cancer Biology from Harvard University. She has a long-standing interest in cancer etiology, and the intersection of environmental exposures and genetics in increasing cancer susceptibility. Her recent work has focused on inter-individual variation in immunity in cancer risk and outcome. Specific cancers of interest include skin cancer, head and neck cancer, mesothelioma, bladder and lung cancer.
- B.A., Hamline University
- M.P.H., University of Minnesota
- Ph.D., Harvard University
- 1998 – 1999: Post-doctoral fellow, Molecular Epidemiology
- 1999 – 2002: Research Associate, Department of Cancer Cell Biology
Harvard School of Public Health
- 2002 – 2007: Assistant Professor of Environmental Epidemiology
Department of Environmental Health, Harvard School of Public Health
- 2007 – present: Associate Professor, Division of Epidemiology and Community Health, University of Minnesota
- 1990 – 1992. Walter Kenyon Scholarship in Biology, Hamline University
- 1992, Walter Kenyon Award, Outstanding Senior in Biology, Hamline University
- 1992, Magna Cum Laude, Hamline University
- 1995, Histopathobiology of Neoplasia fellowship, American Association for Cancer Research
- 1996 – 1998, Albert J. Ryan Fellow, Harvard University
- 1996, Delta Omega Society
- 1997, EMS Scholar Travel Award, Environmental Mutagen Society
- 1998, AACR-Glaxo Wellcome Oncology Clinical Research Scholar Award, American Association for Cancer Research
- 2001, First Decade Award, Hamline University
- 2005, Junior Faculty Sabbatical Award, Harvard School of Public Health
- Genetic susceptibility to environmentally-induced cancers, including skin cancer, mesothelioma, head and neck cancer, bladder cancer and lung cancer
- Inter-individual variation in immune function in cancer etiology and clinical outcome
- Epigenetics in cancer etiology
- Michaud, DS, Houseman, EA, Marsit, C, Nelson, HH, Wiencke, JK, Kelsey, KT. Understanding the role of the immune response in cancer: new opportunities for population-based research. Cancer Epidemiology Biomarkers and Prevention, 2015
- Liang, C, Kelsey, KT, Patel, A, McClean, M, Christensen, BC, Marsit, CJ, Karagas, MR, Waterboer, T, Pawlita, M, Nelson, HH. A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk. Plos One 10(4):e0123716, 2015
- Lazovich, D, Vogel, RI, Weinstock, MA, Nelson, HH, Ahmed, RL, Berwick, M. Indoor tanning – a factor in diverging trends in melanoma among young men and women. JAMA Dermatology, 2015
- Tan, X, Nelson, HH, Langevin, SM, McClean, M, Marsit, CM, Pawlita, M, Kelsey, KT, Michaud, DS. Obesity and head and neck cancer risk and survival by human papillomavirus status. Cancer Causes and Control 26(1):111-9, 2015
- Allen, EM, Alexander, BH, MacLehose, RF, Nelson, HH, Ramachandran, G, Mandel, JF. Occupational exposures and lung cancer risk among Minnesota taconite mining workers. Occup Environ Med72(9):633-39, 2015
- Xu, L, Qu, YH, Chu, X-D, Wang, R, Nelson, HH, Gao, YT, Yuan, J-M. Urinary levels of N-nitroso compounds in relation to risk of gastric cancer: findings from the Shanghai Cohort Study. PLoS One 10(2):e0117326, 2015
- Vineretsky, KA, Karagas, MR, Kuriger, JK, Nelson, HH. HLA-C -35kb expression SNP is associated with differential control of B-HPV infection in squamous cell carcinoma cases and controls. PLoS One 9(8):e103710, 2014
- Farzan, SF, Karagas, MR, Christensen, BC, Li, Z, Kuriger, JK, Nelson, HH. RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer. PLoS One 9(4):e93602, 2014
- Vogel, RI, Ahmed, RL, Nelson, HH Berwick, M, Weinstock, MA, Lazovich, D. Expsoure to indoor tanning without burning and melanoma risk by sunburn history. J Natl Cancer Inst 106(7):219, 2014
- Karagas, MR, Zens, MS, Li, Z, Stukel, TA, Perry, AE, Gilbert-Diamond, D, Sayarath, V, Stephenson, RS, Nelson, HH, Spencer, SK. Early-onset basal cell carcinoma and indoor tanning: a population-based study. Pediatrics 134:e4-12, 2014
- Accomando, WP, Wiencke, JK, Houseman, EA, Nelson, HH, Kelsey, KT. Quantitative reconstruction of leukocyte subsets using DNA methylation. Genome Biology 15(3):R50, 2014
- Michaud, DS, Langevin, SM, Eliot, M, Nelson, HH, Pawlita, M, McClean, MD, Kelsey, KT. High-risk HPV types and head and neck cancer. Int J Cancer, 2014
- Felices, M, Ankarlo, DE, Lenvik, TR, Nelson, HH, Blazer, BR, Verneris, MR, Miller, JS. Notch signaling at later stages of Natural Killer cell development enhances KIR expression and functional maturation. J Immunology, 193(7):3344-54, 2014
- Langevin, SM, Houseman, EA, Accomando, WP, Koestler, DC, Christensen, BC, Nelson, HH, Karagas, MR, Marsit, CJ, Wiencke, JK, Kelsey, KT. Leukocyte-adjusted epigenome-side association studies of blood from solid tumor patients. Epigenetics 9(6), 2014
- Yuan, JM, Butler, LM, Gao, YT, Murphy, SE, Carmella, SG, Wang, R, Nelson, HH, Hecht, SS. Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in The Shanghai Cohort Study. Carcinogenesis, 35(2):339-45, 2014
Dr. Oliver is an entomologist and vector borne disease specialist who studies the interaction of pathogenic bacteria with their arthropod vectors. The diseases and vectors being studied by Dr. Oliver are of particular public health importance in Minnesota and throughout the world.
- Ph.D. – Entomology, Iowa State University (2011-2016)
- B.S. – Anthropology, University of Oregon (1994-1998)
- Effects of pathogen/vector/vertebrate reservoir interactions on disease transmission
- Environmental and microbiotic factors affecting vector range expansion and human exposure to disease
- Development of transgenic and/or paratransgenic ticks incapable of transmitting human pathogens
- Discovery of target proteins for limiting pathogen establishment in vectors and transmission to humans
- 2016 -present, Assistant Professor, Division of Environmental Health Sciences, School of Public Health, University of Minnesota
- 2011-2016, Research Associate/Senior Scientist 6, Department of Entomology, University of Minnesota
Honors and Awards
- Distinguished Academic Staff (Science) Award – University of Minnesota College of Food, Agriculture, and Natural Resource Sciences – 2016
- American Society for Rickettsiology travel awards – 2012 & 2013
- Iowa State University Entomological Graduate Student Organization – President – 2008-2009
- Iowa State University Entomological Graduate Student Organization – Treasurer – 2008-2009
- The Ohio State University Acarology Summer Program, Medical-Veterinary Acarology – 2008
- Wayne A. Rowley Scholarship, Iowa State University, Dept. of Entomology – 2008
- Wayne A. Rowley Scholarship, Iowa State University, Dept. of Entomology – 2007
- GLynn GE, Burkhardt NY, Felsheim RF, Nelson CM, Oliver JD, Kurtti TJ, Munderloh UG. 2016. Characterization and transformation of Ehrlichia isolated from a Minnesota tick. Applied and Environmental Microbiology. Under review.
- Oliver JD, Lynn GE, Burkhardt NY, Price LD, Nelson CM, Kurtti TJ, Munderloh UG. 2015. Infection of immature Ixodes scapularis (Acari: Ixodidae) by membrane feeding. Journal of Medical Entomology. Dec 31. pii: tjv241.
- Chávez ASO, Fairman JW, Felsheim RF, Nelson CM, Herron MJ, Higgins L, Oliver JD, Markowski TW, Kurtti TJ, Edwards TE, Munderloh UG. 2015. Methylation of an Anaplasma phagocytophilum outer membrane protein is required for infection of tick cells. PLOS Pathogens. Nov 6; 11(11):e1005248.
- Oliver JD, Chávez ASO, Felsheim RF, Kurtti TJ, Munderloh UG. 2015. An Ixodes scapularis cell line with a predominantly neuron-like phenotype. Experimental and Applied Acarology. Jul; 66(3):427-42.
- Lynn GE, Oliver JD, Nelson CM, Felsheim RF, Kurtti TJ, Munderloh UG. 2015. Tissue distribution of Ehrlichia muris-like agent in a tick vector. PLOS ONE. 2015 Mar; 10(3):e0122007.
- Kurtti TJ, Felsheim RF, Burkhardt NY, Oliver JD, Heu CC, Munderloh UG. 2015. Rickettsia buchneri sp. nov.: a rickettsial endosymbiont of the blacklegged tick Ixodes scapularis. International Journal of Systematic and Evolutionary Microbiology. Mar; 65(Pt 3):965-70.
- Oliver JD, Burkhardt NY, Felsheim RF, Kurtti TJ, Munderloh UG. 2014. Motility characteristics are altered for Rickettsia bellii transformed to overexpress a heterologous rickA. Applied and Environmental Microbiology. Feb; 80(3):1170-6.
- Oliver JD, Loy JD, Parikh GR, Bartholomay LC. 2011. Comparative analysis of hemocyte phagocytosis between six species of arthropods as measured by flow cytometry. Journal of Invertebrate Pathology. Oct; 108(2): 126-130.
- Parikh GR, Oliver JD, Bartholomay LC. 2009. A haemocyte tropism for an arbovirus. Journal of General Virology. Feb; 90(pt. 2): 292-296.
- Oliver JD, Holscher K, Hutcheson HJ, Bartholomay LC. 2007, 2010. Ticks and tick-borne diseases in Iowa. Iowa State University Extension Publications, PM2036.
James (Jim) Pankow received his doctorate and master’s degrees in epidemiology from the University of Minnesota. His primary research interest is the genetic epidemiology of cardiovascular disease and its associated risk factors. He conducts research o the epidemiology of type 2 diabetes, including genetic determinants. He teaches Epidemiologic Methods II and Epidemiologic Methods III Lab.
- Doctor of Philosophy in Epidemiology, University of Minnesota, Minneapolis, MN
- Master of Public Health in Epidemiology, University of Minnesota, Minneapolis, MN
- Bachelor of Science in Biological Sciences, University of Notre Dame, Notre Dame, IN
Cardiovascular Disease, Diabetes, Epidemiology, Genetics
- Professor, University of Minnesota, 2011-present
- Division Training Committee Chair, 2012-present
- Graduate Faculty, Master of Development Practice in International Development (2009-present) University of Minnesota
- Graduate Faculty, Minor in Public Health, University of Minnesota (2008-present)
- Graduate Faculty, Minor in Human Genetics, University of Minnesota (2005-present)
- Associate Professor, University of Minnesota, 2003-2011
- Program Director, Epidemiology MPH Degree, 2007-2011
- Assistant Professor, University of Minnesota, 2001-2003
- Assistant Professor, University of North Carolina at Chapel Hill, 1997-2001
- Delta Omega Honorary Society in Public Health, 1997
- Palmer ND, Goodarzi MO, Langefeld CD, Wang N, Guo X, Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T, Ziegler JT, Williams AH, Stefansovski D, Cui J, Mackay AW, Henkin LF, Bergman RN, Gao X, Gauderman J, Varma R, Hanis CL, Cox NJ, Highland HM, Below JE, Williams AL, Burtt NP, Aguilar-Salinas CA, Huerta-Chagoya A, Gonzalez-Villalpando C, Orozco L, Haiman CA, Tsai MY, Johnson C, Yao J, Rasmussen-Trovik L, Pankow J, et al. Genetic variants associated with quantative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium. Diabetes 2015; 64(5): 1853-1866. PMCID: PMC4407862
- Robbins JR, Petrone AB, Carr JJ, Pankow JS, Hunt SC, Heiss G, et al. Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study. American Heart Journal 2015; 169(3): 371-378. PMCID: PMC4346707
- Weng LC, Cushman M, Pankow JS, Basu S, Boerwinkle E, Folsom AR, Tang W. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: The ARIC Study. Human Molecular Genetics 2015; 24(8): 2401-2408. PMCID: PMC4375421
- Folsom AR, Tang W, Roetker NS, Kishirsagar AV, Derebail VK, Lutsey PL, Pankow JS, et al. Prospective study of sickle cell trait and venous thromboembolism incidence. Journal of Thrombosis and Haemostasis 2015; 13(1): 2-9. PMCID: PMC4294976
- Wassel CL, Berardi C, Pankow JS, Larson NB, Decker PA, Hanson NQ, et al. Soluble P-selectin predicts lower extremity peripheral artery disease incidence and change in the ankle brachial index: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2015; 239: 405-411. PMCID: PMC4361295.
- Berardi C, Larson NB, Decker PA, Wassel CL, Kirsch PS, Pankow JS, et al. Multi-ethnic analysis reveals soluble L-selectin may be post-transcriptionally regulated by 3’UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA). Human Genetics 2015; 134: 393-403. PMCID: PMC4355192.
- Bielinski SJ, Berardi C, Decker PA, Kirsch PS, Larson NB, Pankow JS, et al. P-selectin and subclinical and clinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 2015; 240: 3-9. PMCID: PMC4397161
- Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, … Pankow JS, et al. Low frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications 2015; 6: 5897. PMCID: PMC4311266.
- Bihlmeyer NA, Brody JA, Smith A, Lunetta KL, Nalls M, Smith JA, Tanaka T, Davies G, Yu L, Mirza S, Teumer A, Coresh J, Pankow JS, et al. Genetic diversity is a predictor of mortality in humans. BMC Genetics 2014; 29(15): 1274. PMCID: PMC4301661.
- Lai LY, Petrone AB, Pankow JS, Arnett DK, North KE, Ellison RC, et al. Lack of association of Apolipoprotein E (ApoE) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study. Diabetes/Metabolism Research and Reviews 2015; 239(2): 405-411. PMCID: PMC4361295
- Tang W, Cushman M, Green D, Rich SS, Lange LA, Yang Q, Tracy RP, Tofler GH, Basu S, Wilson JG, Keating BJ, Weng LC, Taylor HA, Jacobs DR, Delaney JA, Palmer CD, Young T, Pankow JS, et al. Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans.American Journal of Hematology 2015; 90(6): 534-540. PMCID: PMC – Journal in Process
- Knowles JW, Xie W, Zhang Z, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, et al, RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) consortium, EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) study, GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) consortium, SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) study, Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. Journal of Clinical Investigation 2015; 125(4): 1739-1751. PMCID: PMC4409020
- Reis JP, Michos ED, Pankow JS, Selvin E, Lutsey PL. Race, vitamin D binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Clinical Nutrition 2015; 101(6): 1232-1240. PMCID: PMC4441813
- Parrinello CM, Lutsey PL, Ballantyne CM, Folsom AR, Pankow JS, Selvin E. Six-year change in high-sensitivity C-reactive protein and risk of diabetes, cardiovascular disease, and mortality. American Heart Journal, 2015;170(2):380-389. PMCID: PMC4548857
- Wu, Pankow JS, Guan W. Sequence kernel association analysis of rare variant set based on the marginal regression model for binary traits. Genetic Epidemiology 2015; 39(6): 399-405. PMCID: PMC4544778
- Lutsey PL, Michos ED, Misialek JR, Pankow JS, Loehr L, Slevin E, Reis JP, Gross M, Eckfeldt JH, Folsom AR. Race and vitamin D binding protein gene polymorphisms modify the association of 25-hydroxyvitamin D and incident heart failure: The ARIC (Atherosclerosis Risk in Communities) Study. Journal of the American College of Cardiology Heart Failure 2015; 3(5): 347-356. PMCID: PMC4426050
- Larson NB, Berardi C, Decker PA, Wassel CL, Kirsch PS, Pankow JS, et al. Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA). Annals of Human Genetics 2015; 79(4): 264-274. PMCID: PMC4474777
- Schneider AL, Lutsey PL, Selvin E, Mosley TH, Sharrett AR, Carson KA, Post WS, Pankow JS, et al. Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study. European Journal of Neurology 2015; 22(8): 1220-1227. PMCID: PMC4496
- Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, … Pankow JS, et al. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Nature Genetics 2015; 47(12): 1415-1425. PMCID: PMC4666734
- Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, … Pankow JS, et al. CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, et al. The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study. PloS Genetics 2015; 11(10): e1005378. PMCID: PMC4591371
- Luft VC, Duncan BB, Schmidt M, Chambless LE, Pankow JS, Hoogeveen RC, Couper DJ. Heiss G. Carboxymethyl ysine, an advanced glycation end product and incident diabetes: A case-control analysis of the ARIC Study. Diabetes Medicine, in press.
- Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, … Pankow JS, et al. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: A meta-analysis of 50,345 Caucasians. American Journal of Clinical Nutrition 2015; 102(5): 1266-1278. PMCID: PMC4625584
- Nelson EJ, Hughes J, Oakes JM, Pankow JS, Kulasingam SL. Geospatial patterns of human papillomavirus vaccine uptake in Minnesota. British Medical Journal Open Access 2015; 5(8): PMCID: PMC4554895
- Folsom AR, Tang W, Roetker NS, Heckbert SR, Cushman Pankow JS. Prospective study of circulating factor XI and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). American Journal of Hematology 2015; 90(11): 1047-1051. PMCID: PMC4618026
- Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, et al. Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference. Obesity (Silver Spring) 2015; 23(7): 1493-1501. PMCID: PMC4482015
- Maruthur NM, Li M, Halushka MK, Astor BC, Pankow JS, Boerwinkle E, et al. PloS One 2015; 10(6): e0128452. PMCID: PMC4471120
- Ray D, Li X, Pan W, Pankow JS, Basu S. A Bayesian partitioning model for the detection of multi-locus effects in case-control studies. Human Heredity 2015; 79(2): 69-79. PMCID: PMC4499013
- Selvin E, Rawlings AM, Lutsey PL, Maruthur N, Pankow JS, Steffes M, Coresh J. Fructosamine and glycated albumin and the rest of cardiovascular outcomes and death. Circulation 2015; 1324: 269-277. PMCID: PMC4612521
- Michos ED, Misialek JR, Selvin E, Folsom AR, Pankow JS, Post WS, Lutsey PL. 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC Study. Atherosclerosis 2015; 241(1): 12-17. PMCID: PMC4466162
- Demerath EW, Guan W, Grove ML, Aslibekyan S, Mendelson M, Zhou YH, … Pankow JS, Boerwinkle E. Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci. Human and Molecular Genetics 2015; 24(15): 4464-4479. PMCID: PMC4492394
- Wu B, Pankow JS. Statistical methods for association tests of multiple continuous traits in genome-wide association studies. Annals of Human Genetics 2015; 79(4): 282-293. PMCID: PMC4474745
- Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, … Pankow JS, et al. Directional dominance on stature and cognition in diverse human populations. Nature 2015;523(7561):459-62.
- Selvin E, Rawlings A, Lutsey P, Maruthur N, Pankow JS, Steffes M, Coresh J. Association of 1,5-anhydroglucitol with cardiovascular disease and mortality. Diabetes 2016; 65: 201-208.
- Christoph MJ, Allison MA, Pankow JS, Decker PA, Kirsch PS, Tsai MY, et al. Impact of adiposity on cellular adhesion: The Multi-Ethnic Study of Atherosclerosis (MESA). Obesity (Silver Spring) 2016; 24: 223-230.
- Ray D, Pankow JS, Basu S. USAT: A unified score-based association test for multiple phenotype-genotype analysis. Genetic Epidemiology 2016; 40(1): 20-34. PMCID: PMC – Journal in Process
- Folsom AR, Tang W, Weng LC, Roetker NS, Cushman M, Basu S, Pankow JS. Replication of a genetic risk score for venous thromboembolism in whites but not African Americans. Journal of Thrombosis and Haemostasis 2016; 14: 83-88.
- Reis JP, Selvin E, Pankow JS, Michos ED, Rebholz CM, Lutsey PL. Parathyroid hormone is associated with incident diabetes in white, but not black adults: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes & Metabolism 2016, in press.
- Pankow JS, Decker PA, Berardi C, Hanson NQ, Sale M, Tang W, Kanaya AM, Larson NB, Tsai MY, Wassel CL, Bielinski SJ. Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetic Medicine 2016, in press.
Cavan Reilly’s primary research interest is in statistical genomics/bioinformatics, mainly using Bayesian methods. Currently he is working on methods for analysis of longitudinal studies of gene expression and methods for the analysis of metagenomic analysis. Most of his applied research deals with problems in HIV/AIDS however he also works with studies of pulmonary disorders such as COPD and cystic fibrosis.
- Ph.D., Statistics, Columbia University, 2000
- M.S., Statistics, Columbia University, 1997
- M.A., Economics, New School for Social Research, 1995
- B.S., Sociology, University of Minnesota, 1993
Bayesian Analysis, Bioinformatics, Biostatistics, Clinical Research, Computational Biology, Genetics, Infectious Disease: HIV / AIDS, Statistical Genetics
- 2000-Present, Assistant Professor, Division of Biostatistics, School of Public Health, University of Minnesota
- Reilly C, Haase AT, Schacker TW, Krason D, Wietgrefe S (2002), “The clustering of infected SIV cells in lymphoid tissue”, Journal of American Statistical Association, 97, 943–954.
- Reilly C, Wang C, Rutherford M (2003), “Normalization of microarrays using the transcripts that are not differentially expressed”, Journal of the American Statistical Association, 98, 868-878.
- Reilly C (2005), “Non-parametric longitudinal analysis via a set of survival problems with application to the analysis of microarrays”, Biostatistics, 6, 271–278.
- Hataye J, Moon JJ, Khoruts A, Reilly C, Jenkins M (2006), “Naive and memory CD4+ T cell survival controlled by clonal abundance”, Science, 312, 114–116.
- Reilly C, Raghavan A, Bohjanen P (2006), “Global assessment of cross-hybridization for oligonucleotide arrays”, Journal of Microbiological Techniques, 17, 163–172.
Xiao G, Reilly C, Martinez-Vaz B, Pan W, Khodursky AB
Improved detection of differentially expressed genes through incorporation of gene locations
Research Report 2005-28, Division of Biostatistics, University of Minnesota, 2005
Weihong Tang earned an M.D. in preventive medicine from West China University of Medical Sciences in Chengdu, China, and an M.S. in epidemiology from Peking Union Medical College in Beijing, China. She earned a Ph.D. in epidemiology from the University of Minnesota. Her research interests include the genetic risk factors that contribute to cardiovascular disease.
- Ph.D. in Epidemiology, University of Minnesota
- M.S. in Epidemiology, Peking Union Medical College, Beijing, China
- M.D. in Preventive Medicine, West China University of Medical Sciences, Chengdu, China
- July 2015-present, Associate Professor, Division of Epidemiology and Community Health, University of Minnesota.
- December 2007-June 2015, Assistant Professor, Division of Epidemiology and Community Health, University of Minnesota
- 2004-2007, Research Associate, Division of Epidemiology and Community Health, University of Minnesota
- 2001-2004, Postdoctoral Fellow, NHLBI Training Grant in Cardiovascular Disease Genetic Epidemiology, Division of Epidemiology and Community Health, University of Minnesota
- 1994-1995, Research Scientist, Division of Epidemiology, Peking Union Medical College, Beijing, China
- April 2012-present, Fellow, American Heart Association
Most recent publications first. * equally contributing first author
- Christoph MJ, Allison MA, Pankow JS, Decker PA, Kirsch PS, Tsai MY, Sale MM, de Andrade M, Sicotte H, Tang W, Hanson NQ, Berardi C, Wassel CL, Larson NB, Bielinski SJ. Impact of adiposity on cellular adhesion: The Multi-Ethnic Study of Atherosclerosis (MESA). Obesity (Silver Spring) 2015, in press, doi: 10.1002/oby.21245. [Epub ahead of print]
- Folsom AR, Tang W, Weng LC, Roetker NS, Cushman M, Basu S, Pankow JS. Replication of a genetic risk score for venous thromboembolism in whites but not in African Americans. Journal of Thromboembolism and Haemostasis 2015, in press, doi: 10.1111/jth.13193. [Epub ahead of print]
- van Loon J, Dehghan A, Tang W, Trompet S, McArdle WL, Asselbergs FF, Chen MH, Lopez LM, Huffman JE, Leebeek FW, Basu S, Stott DJ, Rumley A, Gansevoort RT, Davies G, Wilson JJ, Witteman JC, Cao X, de Craen AJ, Bakker SJ, Psaty BM, Starr JM, Hofman A, Wouter Jukema J, Deary IJ, Hayward C, van der Harst P, Lowe GD, Folsom AR, Strachan DP, Smith N, de Maat MP, O’Donnell C. Genome-wide association studies identify genetic loci for low von Willebrand factor levels. European Journal of Human Genetics 2015, in press, doi: 10.1038/ejhg.2015.222. [Epub ahead of print].
- Folsom AR, Tang W, Roetker NS, Heckbert SR, Cushman M, Pankow JS. Prospective study of circulating factor XI and incident venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology (LITE). American Journal of Hematology 2015; 90(11):1047-1051. PMCID: PMC4618026.
- Folsom AR, Yao L, Alonso A, Lutsey PL, Missov E, Lederle FA, Ballantyne CM, Tang W. Circulating biomarkers and abdominal aortic aneurysm incidence: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 2015;132(7):578-585. PMCID: PMC4543558
- Tang W, Cushman M, Green D, Rich SS, Lange LA, Yang Q, Tracy RP, Tofler GH, Basu S, Wilson JG, Keating BJ, Weng LC, Taylor HA, Jacobs DR Jr, Delaney JA, Palmer CD, Young T, Pankow JS, O’Donnell CJ, Smith ML, Reiner AP, Folsom AR. Gene-centric approach identifies new and known loci for FVIII activity and VWF antigen levels in European Americans and African Americans. American Journal of Hematology 2015;90(6):534-540. PMCID: PMC – Journal in Process.
- Germain M, Chasman DI, de Haan H, Tang W, Lindstrom S, Weing LC, de Andrade M, de Visser MCH, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, Hao K, Nelson CP, Rocamin-Arjo A, Folkersen L, Monajemi R, Rose LM, Brody JA, Slagboom E, Aissi D, Gagnon F, Deleuze JF, Deloukas P, Tzourio C, Dartigues JF, Berr C, Taylor KD, Civelek M, Eriksson P, Cardiogenics Consortium, Psaty BM, Houwing-Duitermaat J, Goodall AH, Cambien F, Kraft P, Amouyel P, Samani NJ, Basu S, Ridker PM, Rosendaal FR, Kabrhel C, Folsom AR, Heit J, Reitsma PH, Tregouet DA, Smith NL, Morange PE, on behalf of the INVENT consortium. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. American Journal of Human Genetics 2015;96(4):532-542. PMCID: PMC4385184.
- Weng LC, Cushman M, Pankow JS, Basu S, Boerwinkle E, Folsom AR, Tang W. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: The ARIC Study. Human Molecular Genetics 2015;24(8):2401-2408. PMCID: PMC4375421.
- Li S, Miao S, Huang Y, Liu Z, Tian H, Yin X, Tang W, Steffen LM, Xi B. Fruit intake decreases risk of incident type 2 diabetes: An updated meta-analysis. Endocrine 2015;48(2):454-460. PMCID: PMC – Journal in Process.
- Munir MS, Weng LC, Tang W, Basu S, Pankow JS, Matijevic N, Cushman M, Boerwinkle E, Folsom AR. Genetic markers associated with plasma protein C level in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study. Genetic Epidemiology 2014;38(8):709-713. PMCID: PMC4354842.
- Weng LC, Tang W, Rich SS, Smith NL, Redline S, O’Donnell CJ, Basu S, Reiner AP, Delaney JA, Tracy RP, Palmer CD, Young T, Yang Q, Folsom AR, Cushman M. A genetic association study of D-dimer levels with 50K SNPs from a candidate gene chip in four ethnic groups. Thrombosis Research 2014;134(2):462-7. PMCID: PMC4111961.
- Guan W, Steffen BT, Lemaitre RN, Wu JH, Tanaka T, Manichaikul A, Foy M, Rich SS, Wang L, Nettleton JA, Tang W, Gu X, Bandinelli S, King IB, McKnight B, Psaty BM, Siscovick D, Djousse L, Ida Chen YD, Ferrucci L, Fornage M, Mozafarrian D, Tsai MY, Steffen LM. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. Cardiovascular Genetics 2014;7(3):321-331. PMCID: PMC4123862.
- Berardi C, Decker PA, Kirsch PS, de Andrade M, Tsai MY, Pankow JS, Sale MM, Sicotte H, Tang W, Hanson N, Polak JF, Bielinski SJ. Plasma and serum L-selectin and clinical and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Translational Research 2014;163(6):585-92. PMCID: PMC4029851.
- Xi B, Li S, Liu Z, Tian H, Yin X, Huai P, Tang W, Zhou D, Steffen LM. Intake of fruit juice and incidence of type 2 diabetes: A systematic review and meta-analysis. PloS One 2014;9(3):e93471. PMCID: PMC3969361.
- Huang J, Huffman JE, Yamkauchi M, Trompet S, Asselbergs FW, Sabater-Lleal M, Treqouet DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W, Dehghan A, Johnson AD, Truong V, Folkersen L, Yang Q, Qudot-Mellkah T, Buckley BM, Moore JH, Williams FM, Campbell H, Silbernagel G, Vitart V, Rudan I, Tofler GH, Navis GJ, Destefano A, Wright AF, Chen MH, de Craen AJ, Worrall BB, Rudnicka AR, Rumley A, Bookman EB, Psaty BM Chen F, Keene KL, Franco OH, Bohm BO, Uitterlinden AG, Carter AM, Jukema JW, Sattar N, Bis JC, Ikram MA; The Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium Neurology Working Group, Sale MM, McKnight B, Fornage M, Ford I, Taylor K, Slagboom PE, McArdle WL, Hsu FC, Franco-Cereceda A, Goodall AH, Yanek LR, Furie KL, Cushman M, Hofman A, Witteman JC, Folsom AR, Basu S, Matijevic N, van Gilst WH, Wilson JF, Westendorp RG, Kathiresan S, Reilly MP, The CARDIoGRAM Consortium, Tracey RP, Polasek O, Winkelmann BR, Grant PJ, Hillege HL, Cambien F, Stott DJ, Lowe GD, Spector TD, Meigs JB, März W, Eriksson P, Becker LC, Morange PE, Soranzo N, Williams SM, Hayward C, van der Harst P, Hamsten A, Lowenstein CJ, Strachan DP, O’Donnell CJ; The CHARGE Consortium Hemostatic Factor Working Group. Genone-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arteriosclerosis Thrombosis and Vascular Biology 2014;34(5):1093-1101. PMCID: PMC4009733.
- Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ; VTE Consortium; STROKE Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2); C4D Consortium; CARDIoGRAM Consortium, Wallaschofski H, Smith NL, Tregouet D, Ridker PM*, Tang W*, Strachan DP*, Hamsten A*, O’Donnell CJ*. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation 2013;128(12):1310-1324. PMCID: PMC3842025.
- Tang W, Morrison A, Wasserman BA, Folsom AR, Sun W, Campbell S, Kao WHL, Boerwinkle E. Association of SERPINA9 gene variants with carotid artery atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. International Journal of Molecular Epidemiology and Genetics 2013:4:258-267. PMCID: PMC3852645.
- Folsom AR, Pankow JS, Li X, Duprez DA, Jacobs DR Jr, Klein R, Klein B, Tang W, Wong TY, Cotch MF, Taylor KD, Rich SS, Hall JL, Post WS, Rotter JI. No association of 9p21 with arterial elasticity and retinal microvascular findings. Atherosclerosis 2013;230:301-303. PMCID: PMC3787319.
- Tang W, Teichert M, Chasman D, Heit J, Morange P, Li G, Pankratz N, Leebeek F, Pare G, de Andrade M, Tsourio C, Psaty B, Basu S, Ruiter R, Rose L, Armasu S, Lumley T, Heckbert S, Uitterlinden A, Lathrop M, Rice K, Cushman M, Hofman A, Lambert J-C, Glazer N, Pankow J, Witteman J, Amouyel P, Bis J, Bovill E, Kong X, Tracy R, Boerwinkle E, Rotter J, Tre’goue’t D-A, Loth D, Stricker B, Ridker P, Folsom A, Smith N. A genome-wide association study for venous thromboembolism: The Extended Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Genetic Epidemiology 2013;37(5):512-521. PMCID: PMC3990406.
- Lynch AI, Tang W, Shi G, Devereux RB, Eckfeldt JH, Arnett DK. Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN stuy. Journal of Human Hypertension 2012;26(2):133-140. PMCID: PMC3775641.
- Tang W, Schwienbacher C, Lopez LM, Ben-Shlomo Y, Oudot-Mellakh T, Johnson AD, Samani JN, Basu S, Gögele M, Davies G, Lowe GDO, Tregouet DA, Tan A, Pankow JS, Tenesa A, Levy D, Volpato C, Rumley A, Gow AJ, Minelli C, Yarnell JWG, Porteous DJ, Starr JM, Gallacher J, Boerwinkle E, Visscher PM, Pramstaller PP, Cushman M, Emilsson V, Plump AS, Matijevic N, Morange PE, Deary IJ, Hicks AA, Folsom AR. Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease. American Journal of Human Genetics 2012;91(1):152-162. PMCID: PMC3397273.
- Qayyum R, Snively BM, Ziv E, Nalls MA, Liu Y, Tang W, Yanek LR, Lange L, Evans MK, Ganesh S, Austin MA, Lettre G, Becker DM, Zonderman AB, Singleton AB, Harris TB, Mohler ER, Logsdon BA, Kooperberg C, Folsom AR, Wilson JG, Becker LC, Reiner AP. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans. PLoS Genetics 2012;8(3):e1002491. PMCID: PMC3299192.
- Xi B*, Liang Y, Reilly KH, Wang Q, Hu Y, Tang W*. Trends in prevalence, awareness, treatment, and control of hypertension among Chinese adults 1991-2009. International Journal of Cardiology 2012;158:326-329. PMCID: PMC3374129.
- Gieger C*, Radhakrishnan A*, Cvejic A*, Tang W*, Porcu E*, Pistis G*, Serbanovic‐Canic J*, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, Sorice R, Teumer A, Voss K, Zhang W, Ramirez‐Solis R, Bis JC, Ellinghaus D, Gögele M, Hottenga JJ, Langenberg C, Kovacs P, O’Reilly PF, Shin SY, Esko T, Hartiala J, Kanoni S, Murgia F, Parsa A, Stephens J, van der Harst P, van der Schoot CE, Allayee H, Attwood A, Balkau B, Bastardot F, Basu S, Baumeister SE, Biino G, Bomba L, Bonnefond A, Cambien F, Chambers JC, Cucca F, D’Adamo P, Davies G, de Boer RA, de Geus EJC, Döring A, Elliott P, Erdmann J, Evans DM, Falchi M, Feng W, Folsom AR, Frazer IH, Gibson QD, Glazer NL, Hammond C, Hartikaine AL, Heckber SR, Hengstenberg C, Hersch M, Illig T, Loos RJF, Jolley J, Khaw KT, Kühnel B, Kyrtsonis MC, Lagou V, Lloyd‐Jones H, Lumley T, Mangino M, Maschio A, Leach IM, McKnight B, Mitchell YMB, Montgomery GW, Nakamura Y, Nauck M, Navis G, Nöthlings U, Nolte IM, Porteous D, Pouta A, Pramstaller PP, Pullat J, Ring SM, Rotter JI, Ruggiero D, Ruokone A, Sala C, Samani NJ, Sambrook J, Schlessinger D, Schreiber S, Schunkert H, Scott J, Smith NL, Snieder H, Starr JM, Stumvoll M, Takahashi A, Tang WHW, Taylor K, Tenesa A, Thein SL, Tönjes A, Uda M, Ulivi S, van Veldhuisen DV, Visscher PM, Völker U, Wichmann HE, Wiggins KL, Willemsen G, Yang TP, Zhao JH, Zitting P, Bradley JR, Dedoussis GV, Gasparini P, Hazen SL, Metspalu A, Pirastu M, Shuldiner AR, van Pelt LJ, Zwaginga JJ, Boomsma DI, Deary IJ, Franke A, Frogue P, Ganesh SK, Jarvelin MR, Martin NG, Meisinger C, Psaty BM, Spector TD, Wareham NJ, Akkerman JWN, Ciullo M, Deloukas P, Greinacher A, Jupe S, Kamatani N, Khadake J, Kooner JS, Penninger J, Prokopenko I, Stemple D, Toniolo D, Wernisch L, Sanna S*, Hicks AA*, Rendon A*, Ferreira MA*, Ouwehand WH*, Soranzo N*. New gene functions in megakaryopoiesis and platelet formation. Nature 2011;480(7376):201-208. PMCID: PMC3335296
William Toscano received his Ph.D. in biochemistry from the University of Illinois-Urbana. Previously, he was on the faculty of the Harvard School of Public Health and the Tulane School of Public Health and Tropical Medicine. His research interests include the action of dioxins and other polychlorinated compounds on development, the effects of environmental signals on human reproduction, and the creation of transgenic biosensors of environmental toxicants. His teaching interests include environmental microbiology and environmental, occupational, industrial toxicology, toxico-genomics, and molecular approaches to risk assessment.
- Ph.D., Biochemistry, The University of Illinois, Urbana-Champaign
Diabetes, Environmental Health, Genetics, Global Health, Risk Assessment, Toxicology, Women’s Health
- Professor of Molecular Toxicology, University of Minnesota School of Public Health, Minneapolis, MN 55455
- 2000 – 2014 Head Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455
- 2000 Present Interim Head, Center for Environmental Health Policy University of Minnesota, Minneapolis, MN 55455
- 2003 – Present Head, Global Health Initiative, University of Minnesota, School of Public Health, Minneapolis, MN 55455
- 2003- Present Professor of Molecular Toxicology, Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455
- 1999 – Present Professor and Chair, Dept. of Environmental Health Sciences, Tulane University Medical Center School of Public Health & Tropical Medicine, New Orleans, LA 70112
- 1993 – 1999 Co-director Interdisciplinary Program for Molecular Cell Biology Tulane University. New Orleans, LA 70112
- 1994- 1999 Associate Professor of Toxicology, Division of Environmental & Occupational Health, University of Minnesota School of Public Health, Minneapolis, MN 55455
- 1989 – 1993 Associate Professor of Toxicology, Laboratory of Toxicology, Harvard University School of Public Health, Boston, MA 02115
- 1986 – 1989 Assistant Professor of Toxicology, Laboratory of Toxicology, Harvard University School of Public Health, Boston, MA 02115
- Toscano, W. A., Oehlke, K. P., Kafoury, R. M.  An Environmental Systems Biology Approach to the Study of Asthma, in Pawnkar, R., Holgate, S., and Rosenwasser, L. J. eds. Allergy Frontiers: Future Perspectives, 6: 239-252, Springer.
- Toscano, W. A., Lee, P., and Oehlke, K. P.  The Role of Environmental Health Research in Understanding Chronic Diseases, Minnesota Medicine 21: 28-29.
- Toscano, W. A., Mori, C. , Molecular tools for risk assessment, in Robson, M. G., Toscano, W. A., eds, Risk Assessment for Environmental Health, Jossey-Bass, Inc., San Francisco, CA, pp. 155-172.
- Robson, M. G., Toscano, W. A. eds,  Risk Assessment for Environmental Health, Jossey-Bass, Inc., San Francisco, CA, 628 pp.
- Kafoury, R. M., Hernandez, J. M., Lasky, J. A., Toscano, W. A., Jr., Friedman, M.  Activation of TRANSCRIPTION FACTOR IL-6 (NF-IL-6) and Nuclear Factor-κB (NF-κB) by Lipid Ozonation Products is Crucial to Interleukin-8 Gene Expression In Human Airway Epithelial Cells, Environ. Toxicol. (In Press)
- Kandlikar, M., Ramachandran, G., Maynard, A. D., Murdock, B. and Toscano, W. A.  Health risk assessment for nanoparticles: A case for using expert judgment J. Nanoparticle Res. 9: 137-156.
- Lee, D. H., Lee, I. K,. Song K., Steffes, M., Baker, B., Toscano, W. A., and Jacobs , D. A. Jr  A Strong Dose-Response Relation between Serum Concentrations of Persistent Organic Pollutants and Diabetes: Results from the National Health and Examination Survey 1999-2002 Diabetes Care 29: 1638 – 1644.
- Toscano, W. A., Oehlke, K,  Systems Biology: New Approaches to Old Environmental Health Problems. Int. J. Environ. Res. Public Health 2: 4-9.
- Toscano, W., Hovey, C. Hulne, J. Strum, J. Thompson, E.  Children Living in a Perilous Environment. Healthy Generations 4: 6-7. Toscano, W. A., Oehlke, K,  Systems Biology: New Approaches to Old Environmental Health Problems. Int. J. Environ. Res. Public Health 2: 4 – 9.
- Toscano, W. A., Jr., Toscano, D. G., Toscano, J. S., Gross, M. K. , Molecular Modeling of Manganese Regulation of Calmodulin-dependent Adenylyl Cyclase from Mammalian Sperm. BIOCHEM. BIOPHYS. RES. COMMUNIC. 312: 91-96
- Coleman, K. P., Toscano, W. A., Jr., Wiese, T. E.  QSAR Models of the in vitro Estrogen Activity of Bisphenol A. QUANT. STRUCT. ACTIVITY RELAT. 22: 78- 87.
- McLachlan, J. A., Guillette, L. J., Iguchi, T. & Toscano, W. A., Jr.  Environmental Hormones: The Scientific Basis of Endocrine Disruption. NY Academy of Sciences, NY, NY, 142 pp. Book.
- Mattingly, C. J., and Toscano, W. A., Jr.  Posttranscriptional Silencing of Cytochrome P4501A1 During Zebrafish (Danio rerio)Development. Devel. Dynam. 222: 645-654.
- Mattingly, C. J., McLachlan, J. A., & Toscano, W. A., Jr.  Green Fluorescent Protein (GFP) as a Marker of Aryl hydrocarbon receptor (AhR) Function in Developing Zebrafish (Danio rerio). ENVIRON. HEALTH PROSPECT. 109:845-849
Baolin Wu received his Ph.D. in biostatistics from Yale University in 2004. His research interests include functional genomics, proteomics, statistical genetics, multiple hypothesis testing, and machine learning. He currently focuses on developing computational and statistical methods to help solve scientific problems in genetics and biology. He teaches categorical data analysis and biostatistics regression for public health students.
- Ph.D., 2004, Biostatistics, Yale University
Bioinformatics, Biostatistics, Computational Biology, Genetics, Machine Learning, Statistical Genetics
- 2004-Present Tenure-track Assistant Professor, Division of Biostatistics, School of Public Health, University of Minnesota
- 2002-2004 Research Assistant, HHMI Biopolymer/Keck Laboratory, NHLBI Proteomics Center, Yale University
- 1999-2002 Teaching and Research Assistant, School of Public Health, Yale University
- 2005 Award for exemplary application for Grant in Aid of artistry and research, University of Minnesota.
- Wu B. Cancer outlier differential gene expression detection. Biostatistics, kxl029, 2006.
- Wu, B., Guan, Z. and Zhao, H. Parametric and nonparametric FDR estimation revisited. Biometrics, 62:735-744, 2006.
- Wu, B. Differential gene expression detection and sample classification using penalized linear regression models. Bioinformatics, 22: 472-476, 2006.
- Wu, B., Liu, N. and Zhao, H. PSMIX: an R package for population structure inference via maximum likelihood method. BMC Bioinformatics, 7:317, 2006.
- Wu, B., Abbott, T., Fishman, D., McMurray, W., Mor, G., Stone, K., Ward, D., Williams, K., and Zhao, H. Ovarian cancer classification based on mass spectrometry analysis of sera. Cancer Informatics, 2: 123-132, 2006.
- Yu, W., Wu, B., Lin, N., Stone, K., Williams, K., and Zhao, H. Detecting and aligning peaks in mass spectrometry data with applications to MALDI. Computational Biology and Chemistry, 30: 27-38, 2006.
- Yu, W., Wu, B., Liu, J., Li, X., Williams, K., and Zhao, H. MALDI-MS Data Analysis for Disease Biomarker Discovery. In Nedelkov D(ed). New and Emerging Proteomics Techniques, Human Press Inc., Totowa, New Jersey, USA, 2006.
- Yu, W., Wu, B., Huang, T., Li, X., Williams, K., and Zhao, H. Statistical methods in proteomics. In Pham H(ed). Springer Handbook of Engineering Statistics, Springer-Verlag, London, UK, 2006.
- Huang, T., Wu, B., Lizardi, P., and Zhao, H. Detection of DNA Copy Number Alterations Using Penalized Least Squares Regression. Bioinformatics, 21: 3811-3817, 2005.
Cancer outlier differential gene expression detection
Research Report 2006-11, Division of Biostatistics, University of Minnesota, 2006
Flexible prediction analysis of microarrays
Research Report 2006-8, Division of Biostatistics, University of Minnesota, 2006
Statistical applications in genetics and molecular biology, accepted.
Boosting nearest shrunken centroid classifier for microarray data
Research Report 2005-29, Division of Biostatistics, University of Minnesota, 2005
Predictive model building for microarray data using generalized partial least squares model
Research Report 2005-23, Division of Biostatistics, University of Minnesota, 2005
Huang T, Wu B, Lizardi P, Zhao H
Detection of DNA Copy Number Alterations Using Penalized Least Squares Regression
Research Report 2005-17, Division of Biostatistics, University of Minnesota, 2005
Regularized singular value decomposition: a sparse dimension reduction technique
Research Report 2005-2, Division of Biostatistics, University of Minnesota, 2005
A unified statistical framework for differential gene expression detection and sample classification using penalized linear regression models
Research Report 2004-30, Division of Biostatistics, University of Minnesota, 2004
A shortened version to appear in Bioinformatics (revised 2005)
Differential gene expression detection using penalized linear regression model: the improved SAM statistics
Research Report 2004-19, Division of Biostatistics, University of Minnesota, 2004
Guan Z, Wu B, and Zhao H
Nonparametric estimator of false discovery rate based on bernstein polynomials
Research Report 2004-17, Division of Biostatistics, University of Minnesota, 2004
Statistica Sinica, to appear (revised 2006).
Guan Z, Wu B, and Zhao H
Model-Based Approach to FDR Estimation
Research Report 2004-16, Division of Biostatistics, University of Minnesota, 2004
Wu B, Guan Z, and Zhao H
Parametric and Nonparametric FDR Estimation Revisited
Research Report 2004-15, Division of Biostatistics, University of Minnesota, 2004
Biometrics, to appear (revised 2005)