Although commercial tobacco control has been recognized as a top target for public health, commercial tobacco use remains the single largest preventable cause of disease and premature death in the United States. Those experiencing some of the highest rates of commercial tobacco-related disease and death are American Indian persons and those residing in rural America. Reasons for these disparities include aggressive targeting of highly addictive products by the tobacco industry and a legacy of public health prioritizing one-size-fits-all approaches. In this seminar, Dr. Carroll will share about her research efforts involving creation of culturally aligned smoking cessation programs for American Indian persons– efforts that reflect the steadfast support of her community partners, started with a Masonic Cancer Center pilot grant, and have been referenced as part of the Biden-Harris Administration’s Cancer Moonshot Agenda to end cancer. Dr. Carroll will also share on her newer efforts to enhance smoking cessation among adults living in rural America via a multi-level intervention that targets both behavioral and healthcare domains of influence.